What is the impact of Wegovy on mental health and mood?

Wegovy (semaglutide) does not appear to cause depression, anxiety, or other serious mental health problems in most people, based on current UK guidance and available research. Large reviews and safety monitoring have found no clear causal link between semaglutide and increased risk of depression or suicidal thoughts. Some people report improved mood and confidence alongside weight loss. Even so, it’s important to stay alert to any psychological symptoms and discuss changes with a healthcare professional. Regulators continue to monitor GLP-1 medicines for safety as evidence evolves. [1][2][3][4][5]

• Studies and reviews have not shown an increased risk of depression, anxiety, or suicidal thoughts with semaglutide when used as directed. [1][3][4][5]
• Many people feel better mentally as weight, health markers, and daily function improve during treatment. [2][5]
• UK bodies advise monitoring for any new or worsening mood changes during treatment and seeking advice if these occur. [1][3]
• If you experience low mood, anxiety, unusual thoughts, or behavioural changes while taking Wegovy, contact a clinician promptly. [1][3][5]
• Semaglutide’s neurological safety profile is being studied; **current evidence is generally reassuring**, with ongoing pharmacovigilance. [2][3][4]

Sources

• NICE TA875 — Semaglutide for managing overweight and obesity [1]
• NIHR Oxford Health BRC — Brain health study on semaglutide [2]
• BBC News — GLP-1 medicines and mental health: what regulators found [3]
• PubMed Central — Review/analysis related to GLP-1 RAs and neuropsychiatric safety [4]
• Second Nature — Wegovy, anxiety and depression: evidence summary [5]