Should you exercise while on Mounjaro?

Yes—exercise is recommended while taking Mounjaro (tirzepatide). UK guidance expects it to be combined with a reduced-calorie diet and regular physical activity for best results. Physical activity helps enhance weight loss, preserve muscle, improve fitness, and support long-term weight management alongside the medication.

Aim for at least 150 minutes of moderate-intensity activity per week (or 75 minutes vigorous), plus muscle-strengthening activities on 2 or more days. Adjust intensity if you experience side effects like nausea: scale down to lighter activity, prioritise hydration, and rest as needed. If Mounjaro is prescribed through NHS services, participation in lifestyle support and increased physical activity is typically part of the care plan.

• Use exercise with Mounjaro to maximise results—it complements, not replaces, the medicine.
• Target 150 minutes moderate or 75 minutes vigorous activity weekly, plus strength work on 2+ days.
• On days with nausea or GI symptoms, reduce effort, focus on hydration, and resume gradually.
• NHS programmes that prescribe tirzepatide generally expect participation in lifestyle and activity support.
• Regular activity helps preserve muscle and supports long-term weight maintenance.

Sources

• NHS England – Weight management injections
• NICE TA1026 – Tirzepatide for managing overweight and obesity
• NHS – Obesity treatment (diet and physical activity guidance)
• NHS North West London ICB – Tirzepatide and local programme
• Cheshire & Merseyside NHS – Mounjaro prescribing statement