What is the impact of Wegovy on mental health and mood?

Wegovy (semaglutide) does not appear to cause depression, anxiety, or other serious mental health problems for most people, based on recent UK evidence and guidance. Large studies and safety reviews by UK and European bodies have found no clear link between semaglutide and an increased risk of depression or suicidal thoughts. Some people may experience improved mood, confidence, or overall wellbeing as weight reduces, but any changes in mood should still be reported to a healthcare professional. Although rare cases of mood changes have been mentioned, current evidence suggests these are not directly caused by Wegovy; continued monitoring is advised for anyone noticing psychological symptoms while taking it.

• Studies show no increase in depression, anxiety, or suicidal thoughts with Wegovy.
• Some people report improved mood related to weight loss and wider health benefits.
• UK healthcare guidance recommends monitoring for any new mood or behaviour changes during treatment.
• If you experience persistent low mood, anxiety, or unusual thoughts while on Wegovy, contact your doctor promptly.
• Wegovy is closely monitored for side effects in the UK—discuss any concerns with a healthcare professional.

Sources

• NICE TA875 — Semaglutide for managing overweight and obesity (UK guidance)
• NIHR Oxford Health BRC — Semaglutide and brain health/cognition
• BBC News — Regulators find no clear link with suicidal thoughts
• Peer-reviewed review — GLP-1 RAs and psychiatric safety
• Oviva — Wegovy side effects and monitoring advice (UK)