How can you manage fatigue while on Mounjaro?
Feeling tired on Mounjaro (tirzepatide) is fairly common and can often be improved with simple steps focused on hydration, nutrition, sleep, and routine adjustments. Start by drinking fluids regularly, as GLP-1 medicines can blunt thirst and even mild dehydration can worsen fatigue; adding electrolyte drinks or salty foods may help some people. Eat small, regular, nutrient-dense meals with adequate protein and carbohydrates to avoid under-fuelling, which is a frequent cause of low energy on appetite-suppressing treatments. Prioritise consistent sleep, gentle daily activity (like walking), and consider timing injections before rest days. If fatigue persists or is severe—especially if you take diabetes medicines that can lower blood sugar—speak to a GP or pharmacist for review and checks such as iron or vitamin D.
- Stay well hydrated; GLP-1s can reduce thirst and even mild dehydration worsens tiredness.
- Eat regular, balanced meals with enough protein and calories to avoid under-fuelling.
- Consider electrolytes or salty foods if feeling washed out, alongside fluids.
- Keep a steady sleep routine and limit caffeine late in the day.
- Try light activity (e.g., short walks) to support energy and mood.
- Seek medical advice if fatigue is persistent, severe, or if you are on diabetes medicines that can cause low blood sugar.