How does Mounjaro impact sleep?
Mounjaro (tirzepatide) is not known to directly cause insomnia, and insomnia is not listed among its common side effects in UK product information. The most frequent side effects are gastrointestinal, particularly during dose increases. However, some people report sleep disturbances such as difficulty falling asleep, vivid dreams, or next-day tiredness. These are likely linked to nausea, abdominal discomfort, or changes in daily routines rather than a direct effect of the medicine.
Importantly, clinical studies have shown tirzepatide can improve sleep quality in people with obesity and obstructive sleep apnoea, reducing apnoea–hypopnoea events and improving patient-reported outcomes. While experiences vary, evidence suggests Mounjaro does not increase insomnia risk overall and may improve sleep in those with obesity-related sleep problems.
- Insomnia is not listed as a common side effect of tirzepatide; gastrointestinal issues are most typical during dose escalation.
- Some users report sleep problems (e.g., night waking, vivid dreams, fatigue), usually indirect and linked to nausea or adjustment effects.
- Tirzepatide improved obstructive sleep apnoea severity and patient-reported sleep outcomes in long-term trials.
- If sleep problems persist, consult a clinician to review causes and management options.
- Managing GI side effects, keeping a consistent sleep routine, and limiting caffeine or alcohol can help support better sleep while on treatment.