Can Mounjaro be used for weight maintenance after weight loss?
Yes—continuing Mounjaro (tirzepatide) can help maintain weight loss, and stopping it is linked with weight regain in clinical studies. In a withdrawal trial, people who stayed on tirzepatide lost a further ~5.5% on average, while those who stopped regained about 14% of their weight, showing ongoing treatment supports maintenance. UK guidance notes tirzepatide uses maintenance doses (5 mg, 10 mg, or 15 mg weekly) alongside lifestyle measures, and clinicians should periodically review whether to continue or stop based on benefit and tolerance. If treatment is stopped, NICE advises offering support to help maintain any weight lost, emphasising diet and physical activity in UK services.
- Continuing tirzepatide helps maintain—and can further improve—weight loss; stopping is associated with regain in trials.
- Typical maintenance doses are 5 mg, 10 mg, or 15 mg once weekly, reviewed against benefits, side effects, and progress.
- UK guidance pairs tirzepatide with a reduced-calorie diet and regular physical activity for best maintenance results.
- If stopping, UK services should provide support to help keep weight off, such as lifestyle and follow-up care.
- Ongoing monitoring in UK pathways assesses response and decides whether to continue therapy for maintenance.