How long can you stay on Mounjaro?

Most people can stay on Mounjaro long term if it’s working and well tolerated, with regular reviews to confirm ongoing benefit and safety. NHS England’s interim guidance clarifies there is no fixed maximum treatment period or “stopping rule” for tirzepatide; decisions to continue are made case by case by a clinician and may allow indefinite prescribing when benefits outweigh risks. NICE advises reassessing progress, especially if less than 5% weight loss has been achieved after 6 months on the highest tolerated dose, before deciding whether to continue. In practice, treatment may continue to reach a healthy weight and can be maintained thereafter if clinically appropriate, with monitoring through local NHS pathways.

• There is no set maximum duration for Mounjaro; ongoing use can be long term if benefits continue and side effects are acceptable.
• NHS guidance allows case-by-case continuation without a fixed “stopping rule,” including potential indefinite prescribing when appropriate.
• Clinicians should review progress at 6 months on the highest tolerated dose; under 5% weight loss prompts discussion about stopping or alternatives.
• Ongoing follow-up and monitoring should follow local NHS pathways and policies once a stable maintenance dose is reached.
• Decisions about continuing, reducing, or stopping are made with a healthcare professional based on individual benefit-risk balance.

Sources

• NICE – Prescribing, reviewing and stopping tirzepatide (TA1026 practical guide)
• NHS England – Interim commissioning guidance implementing NICE TA1026 (PDF)
• NHS England – Weight management injections overview
• Cheshire & Merseyside NHS – Mounjaro prescribing statement
• Simple Online Pharmacy – How long can you stay on Mounjaro?