How do you transition off Mounjaro safely?

Stopping Mounjaro (tirzepatide) does not cause withdrawal symptoms, but appetite can gradually return and weight regain is common without ongoing lifestyle support. In the UK, the recommended approach is to plan discontinuation with a clinician, continue a reduced-calorie diet and physical activity, and arrange follow-up to maintain progress. NHS and NICE guidance emphasise reviewing response at set intervals and, if stopping, offering ongoing support or referral to weight-management services where appropriate. Because tirzepatide is cleared over about 4 weeks, effects may wear off gradually after the last dose, so maintaining habits through this period is important to reduce rebound weight gain.

• No withdrawal symptoms are expected when stopping tirzepatide, but appetite may increase and weight regain is common without support.
• Plan the stop with a clinician and keep up a reduced-calorie diet and increased physical activity to maintain results.
• If stopping due to limited benefit or side effects, clinicians may review alternatives or refer to weight-management services per UK pathways.
• Expect effects to taper over ~4 weeks after the last dose; prioritise meal planning, activity, and monitoring during this time.
• NICE stresses structured review and, if stopping, continued support to help sustain weight loss.

Sources

• NICE – Practical guide: prescribing, reviewing and stopping tirzepatide
• BNSSG ICB – Tirzepatide (Mounjaro) weight-management guidance
• BNSSG ICB – Tirzepatide training webinar FAQ (clearance/taper FAQs)
• NICE TA1026 – Tirzepatide for managing overweight and obesity
• NHS England – Interim commissioning guidance (TA1026 implementation)