What happens if you stop taking Mounjaro?
Stopping Mounjaro usually leads to appetite returning over a few weeks, which can make it easier to eat more and can result in regaining some of the weight that was lost. Blood sugar may also drift back towards pre-treatment levels, especially in people with type 2 diabetes whose other medicines were reduced while on Mounjaro. Digestive side effects that happened on treatment (like nausea) generally ease after stopping, though some people notice temporary stomach upset as the body readjusts. In UK care, clinicians often recommend a gradual approach and ongoing lifestyle support (diet, activity, behaviour change) to help maintain progress after stopping. Anyone with diabetes or significant weight-related conditions should speak to a GP, pharmacist, or weight-management team before stopping, as other medicines or monitoring may need to be adjusted.
- Expect hunger and food cravings to increase over a few weeks after the last dose, which can lead to weight regain.
- Blood sugar can rise back towards previous levels; people with type 2 diabetes may need medication reviews and closer monitoring.
- Gut symptoms from treatment usually settle after stopping, though short-term stomach upset can occur during the transition.
- A planned stop (or taper) plus continued healthy eating, physical activity, and behaviour support can help maintain weight loss.
- In the UK, discuss stopping with a GP, pharmacist, or NHS/clinic weight-management service to plan follow-up and avoid problems.