How is the Mounjaro dose increased over time?
Mounjaro (tirzepatide) is increased gradually in 2.5 mg steps, with each increase made only after at least 4 weeks on the current dose to help minimise side effects and assess response. In the UK, people usually start at 2.5 mg once weekly for 4 weeks, then move to 5 mg once weekly. If needed and tolerated, the dose can be raised by 2.5 mg every 4 weeks through 7.5 mg, 10 mg, 12.5 mg, and up to a maximum of 15 mg once weekly. Typical maintenance doses are 5 mg, 10 mg, or 15 mg weekly, chosen based on effectiveness and side effects; 7.5 mg and 12.5 mg are mainly intermediate titration steps. Dose adjustments should follow the UK SmPC and NICE guidance, and changes should be overseen by a clinician familiar with local NHS pathways.
- Start at 2.5 mg once weekly for 4 weeks, then increase to 5 mg.
- Increase by 2.5 mg no sooner than every 4 weeks if needed and tolerated.
- Intermediate steps: 7.5 mg, 10 mg, 12.5 mg; maximum dose is 15 mg once weekly.
- Usual maintenance doses are 5 mg, 10 mg, or 15 mg weekly; 7.5 mg and 12.5 mg are primarily for titration.
- Follow the UK SmPC and NICE guidance; dosing should be managed by a healthcare professional within NHS pathways.